ABER known and trusted for it’s sensors that measure live cell concentrations using capacitance technology and adopted in the world’s leading bio pharmaceutical companies from R&D through to cGMP processes brings you the new FUTURApico.
Our Conventional sensors have typically been placed in vessels from 1 litre upwards through to large scale stainless steel vessels of over 250,000.
With the exciting introduction of the FUTURApico system, Aber sensor technology is now available in even smaller bioreactors, as used in R&D, pilot scale and parallel mini bioreactor system typically used for DOE.
Principle of Aber’s cell capacitance technology
Cells with Intact Plasma membranes in a fermenter can be considered to act as tiny capacitors under the influence of an electric field. The non-conducting nature of the plasma membrane allows a build up of charge.
The resulting capacitance can be measured: it is dependant upon the cell type and is directly proportional to the membrane bound volume of these viable cells.
The patented design (Patent no. GB2507283) of the sensor itself takes into consideration the smaller space available for measuring the live cell concentration and utilizes an innovative trapezoidal design to best apply the capacitance field within the vessel.
The sensors electrodes are positioned to maximise the current path around the tip of the probe body.
ABER’s introduction of the FUTURA pico means that this very useful technology can now be introduced earlier during the scale up process, providing key capacitance data that is comparable at all stages of process development making a seamless transition from small scale to conventional bioreactor systems possible.
The advent of Aber’s Futura Pico will further aid PAT processes and support the acquisition of key data to ultimately expedite time to market and return on investment for leading Biopharmas.